The most commonly used treatment for uveal melanoma is radiotherapy. In the months directly following irradiation, patient management should focus on controlling uveitis and monitoring intraocular pressure, alleviating pain, and preventing postoperative infections. If exudative retinal detachment occurs, surgical intervention is not recommended. The detached retina typically reattaches spontaneously as the tumor regresses and vascular leakage diminishes. In cases of choroidal detachment, patient observation is sufficient. For late post-radiation complications, such as retinopathy, neuropathy, and post-radiation maculopathy, treatment with anti-VEGF injections into the vitreous chamber is indicated. Initial therapy consists of three injections at two-month intervals, with continued anti-VEGF treatment as necessary, based on the patient’s response. Cataract surgery is also recommended, when clinically indicated.