The removal of the eyeball is one of the earliest surgical procedures recorded in the history of medicine. The decision to perform enucleation is challenging for both the patient and the physician, and it is typically considered a last resort when all conservative treatment options have been exhausted. In recent years, the number of enucleation procedures performed for advanced glaucoma and intraocular tumors has significantly declined. This is largely due to advancements in laser technology, surgical techniques, and local treatments for glaucoma, as well as the widespread use of radiation therapy for intraocular tumors. Although enucleation can negatively impact the patient’s quality of life and psychological well-being, it remains the treatment of choice in cases of advanced intraocular tumors, extensive eye injuries that preclude the reconstruction of ocular structures, or painful blind eyes. Fortunately, advancements in orbital implants and modern ocular prostheses now offer patients the possibility of achieving a satisfactory cosmetic outcome.