The skin is a barrier between the body and the external environment, it is the largest human organ. Healthy skin microbiota is harmless and beneficial to the skin. As a microbiological barrier, it protects against harmful microorganisms. In turn, the eyelids protect the surface of the eyeball from the adverse effects of external factors. The skin of the eyelids is the thinnest skin in the human body, it is extremely delicate, and does not have subcutaneous fat. The paper discusses eyelid disorders, symptoms accompanying eyelid disorders, including: dry and rough eyelid skin, redness of the eye, a burning/stinging sensation, irritation with a feeling of a foreign body, and others. The author draws attention to the fact that problems with the skin of the eyelids begin when the protective barrier of the skin is breached, which causes an imbalance in the skin microbiota, and the processes that occur then may contribute to the development of skin diseases. The paper discusses the influence of cosmetics on the condition of the eyelid skin, and thus the eye surface, and the importance of trehalose 3%, hyaluronic acid 0.15% and Ophiopogon japonicus 0.3% as ingredients of a cream for the treatment of eyelid skin disorders. The paper discusses the case of a 78-year-old patient treated for many years for glaucoma, with chronic eye surface disorders of a toxic-allergic etiology to the drug reaction, which was treated with the use of the newest three-component cream.